Identification of ethanol‐insensitive <i>N</i>‐methyl‐<scp>d</scp>‐aspartate receptor GluN2A and GluN2B subunit mutants with minimal alterations in ion channel gating
The GluN2A(E413D/F636I/F637I) and GluN2B(G826W) mutant subunits exhibit nearly normal physiology and low alcohol sensitivity. These studies also provide evidence that changes in NMDA receptor ethanol sensitivity are not dependent upon changes in ion channel gating.
Authors
- Rohan Katti (ORCID: https://orcid.org/0000-0002-7068-0174)
- James R. McKee (ORCID: https://orcid.org/0000-0002-5365-4927)
- Priya Katti
- Tapan Mitra
- Robert W. Peoples (ORCID: https://orcid.org/0000-0003-1593-3586)
- Yulin Zhao (ORCID: https://orcid.org/0000-0002-2870-7572)
- Delma Machado Cantisani Pádua
- Joseph Harris
- Hong Ren (ORCID: https://orcid.org/0000-0003-3156-6640)
- Claire M. Fellbaum
- Julia G. Levahn
Institutions
- Marquette University (US)
- Peking University (CN)
- Wuhan Union Hospital (CN)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1111/bph.70107
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Marquette University
- National Institutes of Health
- National Institute on Alcohol Abuse and Alcoholism