The arrow of time in Parkinson’s disease
The arrow of time methodology effectively identifies distinct and informative characteristics of PD. Our analyses suggest that PD shifts the brain towards less efficient, non-equilibrium dynamics that impair intrinsic flexibility and disrupt motor coordination. Thus, these findings not only provide insight into widespread system alterations in PD that could serve as potential biomarkers, but also lay the groundwork for next-generation stimulation techniques aimed at restoring balance in the Parkinsonian brain.
Authors
- Kai Grimm (ORCID: https://orcid.org/0000-0003-3561-3328)
- Simone Zittel (ORCID: https://orcid.org/0000-0002-3767-6376)
- Rainer Goebel (ORCID: https://orcid.org/0000-0003-1780-2467)
- Alessandra Pizzuti (ORCID: https://orcid.org/0000-0002-3311-9118)
- Morten L. Kringelbach (ORCID: https://orcid.org/0000-0002-3908-6898)
- Gustavo Deco (ORCID: https://orcid.org/0000-0002-8995-7583)
- Christian Gerloff (ORCID: https://orcid.org/0000-0002-6484-8882)
- Fatemeh Sadeghi (ORCID: https://orcid.org/0000-0002-9948-5866)
- Abdullah Okar
- Elvira Del Agua Banyeres
Institutions
- Universität Hamburg (DE)
- Universitat Pompeu Fabra (ES)
- Maastricht University (NL)
- University of Oxford (GB)
- University Medical Center Hamburg-Eppendorf (DE)
- Brain Innovation (Netherlands) (NL)
Publication Details
- Journal
- NeuroImage Clinical
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.nicl.2025.103834
- Citations
- 2
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.78