Histopathologic Evaluation and Single-cell Spatial Transcriptomics of the Colon Reveal Cellular and Molecular Abnormalities Linked to J-Pouch Failure in Patients With Inflammatory Bowel Disease
Histologic features including CD68 immunohistochemisty and spatial molecular profiling are predictive of IPAA failure. These findings support the use of histologic evaluation and targeted molecular analysis of the TAC specimen to identify high-risk patients and improve IPAA outcomes.
Authors
- Shintaro Akiyama (ORCID: https://orcid.org/0000-0003-0727-7638)
- Konstantin Umanskiy (ORCID: https://orcid.org/0000-0002-0209-3998)
- David Zemmour (ORCID: https://orcid.org/0000-0002-0990-217X)
- Kinga S. Olortegui
- Emily Schahrer (ORCID: https://orcid.org/0000-0002-7375-9822)
- John Cursio (ORCID: https://orcid.org/0000-0003-2131-1767)
- Eugene B. Chang (ORCID: https://orcid.org/0000-0001-5972-8248)
- Junjie Xing
- David T. Rubin (ORCID: https://orcid.org/0000-0001-5647-1723)
- Andrea D. Olivas (ORCID: https://orcid.org/0000-0001-6176-2621)
- Mobarakeh Ghadiri
- Le Shen (ORCID: https://orcid.org/0000-0002-4367-5476)
- Christopher R. Weber (ORCID: https://orcid.org/0000-0002-2117-3184)
- Patricia Ngai
Institutions
- University of Tsukuba (JP)
- Chicago Department of Public Health (US)
- University of Chicago (US)
- University of Chicago Medical Center (US)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101563
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute of Diabetes and Digestive and Kidney Diseases