Restoration of the gut-microbiota-liver axis after hepatitis C virus eradication
This study offers significant insights into the gut-microbiota-liver axis in patients with chronic hepatitis C following a sustained virological response. The findings demonstrate that HCV eradication promotes partial restoration of the dysbiotic gut microbiota, particularly an increase in the beneficial genus <i>Blautia</i>, as well as a rebalancing of the fecal bile acid profile. These changes are closely associated with significant improvements in liver fibrosis and function, highlighting a potential role of the gut microbiota in liver recovery and regeneration.
Authors
- Jiro Nakayama (ORCID: https://orcid.org/0000-0002-0449-5106)
- Rie Momoda
- Katsuya Nagaoka (ORCID: https://orcid.org/0000-0002-7152-6101)
- Yasuteru Kondo (ORCID: https://orcid.org/0000-0001-5935-4346)
- Yasuhito Tanaka (ORCID: https://orcid.org/0000-0002-2473-6966)
- Kazuhito Kawata (ORCID: https://orcid.org/0000-0002-4986-8578)
- Shuji Terai (ORCID: https://orcid.org/0000-0002-5439-635X)
- Hitoshi Yoshiji (ORCID: https://orcid.org/0000-0002-5243-8544)
- Goki Suda (ORCID: https://orcid.org/0000-0003-0098-9106)
- Takehisa Watanabe (ORCID: https://orcid.org/0000-0001-8990-9496)
- Satoshi Miuma
- Atsushi Toyoda (ORCID: https://orcid.org/0000-0002-0728-7548)
- Atsushi Suetsugu
- Akira Sakamaki (ORCID: https://orcid.org/0000-0002-9368-7272)
- Tatsuya Ide (ORCID: https://orcid.org/0000-0003-4106-6527)
- Yutaka Suzuki (ORCID: https://orcid.org/0000-0003-4852-1879)
- Hideto Kawaratani (ORCID: https://orcid.org/0000-0002-4361-0592)
- Yoichi Hiasa
- Etsuko Iio
- Hisayoshi Watanabe
- Tsunamasa Watanabe (ORCID: https://orcid.org/0000-0002-7659-914X)
- Hiroshi Mori (ORCID: https://orcid.org/0000-0003-0806-7704)
- Satoru Kakizaki (ORCID: https://orcid.org/0000-0003-0224-7093)
- Takao Watanabe (ORCID: https://orcid.org/0000-0002-7929-1781)
- Masaru Tanaka (ORCID: https://orcid.org/0000-0003-2291-7613)
- Kei Moriya (ORCID: https://orcid.org/0000-0002-7500-6728)
- Ken Kurokawa (ORCID: https://orcid.org/0000-0001-8389-3315)
- Daisuke Nakagawa
- Takako Inoue
- Masaya Ohnishi
- Yui Funatsu
Institutions
- National Institute of Genetics (JP)
- Kyushu University (JP)
- St. Marianna University School of Medicine (JP)
- Hokkaido University (JP)
- Hamamatsu University School of Medicine (JP)
- Kurume University Medical Center (JP)
- National Hospital Organization Takasaki Medical Center (JP)
- Nagoya City University Hospital (JP)
- Kyushu Central Hospital of the Mutual Aid Association of Public School Teachers (JP)
- Sendai City Hospital (JP)
- Sendai Shakai Hoken Hospital (JP)
- Sendai Kousei Hospital (JP)
- Gifu University (JP)
- Ehime University (JP)
- Nagasaki University (JP)
- Nara Medical University (JP)
- Niigata University (JP)
- The University of Tokyo (JP)
- Kumamoto University (JP)
Publication Details
- Journal
- JHEP Reports
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1016/j.jhepr.2025.101494
- Citations
- 2
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Japan Agency for Medical Research and Development
- Ministry of Education, Culture, Sports, Science and Technology
- Nagoya City University