Circ-0000197 derived from porcine milk small extracellular vesicles promotes intestinal barrier function by sponging miR-429
These findings emphasize the vital role of circRNAs transported through milk-derived sEV in regulating intestinal health, offering new avenues for developing innovative functional milk components. This mechanism also underscores the importance of PM-sEV carrying circ-0000197 in preserving intestinal barrier integrity. Collectively, this study enhances our understanding of the complex regulatory networks involving PM-sEV carrying circRNAs and their impact on intestinal health.
Authors
- Jiajie Sun (ORCID: https://orcid.org/0000-0003-1992-154X)
- Junyi Luo (ORCID: https://orcid.org/0000-0002-1060-4081)
- Tingzhou Xuan
- Hailong Wang (ORCID: https://orcid.org/0000-0002-6107-5095)
- Yuxuan Wang (ORCID: https://orcid.org/0000-0001-6476-9589)
- Yongliang Zhang (ORCID: https://orcid.org/0000-0001-5157-6059)
- Bin Chen (ORCID: https://orcid.org/0000-0002-5488-6850)
- Ting Chen (ORCID: https://orcid.org/0000-0003-1725-7956)
- Qianyun Xi
- Kun Ouyang
- Jingshen Chen
Institutions
- South China Agricultural University (CN)
Publication Details
- Journal
- Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1186/s40104-025-01218-5
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Agricultural University
- Natural Science Foundation of Guangdong Province
- China Scholarship Council
- South China Agricultural University
- National Key Research and Development Program of China