Continuous Flow Telescoped Synthesis of Benzofurans Starting from Nitroalkanes and O-Acetyl Salicylaldehydes
Abstract Herein, we report a new practical flow chemical synthesis of benzofurans starting from nitroalkanes and O-acetyl salicylaldehydes. The protocol involves two different sequential steps: (i) an initial base-promoted nitroaldol condensation, and (ii) a Nef reaction promoted by tin (II) chloride dihydrate. The target benzofurans are obtained in satisfactory overall yields.
Authors
- Marino Petrini (ORCID: https://orcid.org/0000-0002-4941-5878)
- Alessandro Palmieri (ORCID: https://orcid.org/0000-0001-6599-3937)
- Elettra Gheco
Institutions
- Università di Camerino (IT)
Publication Details
- Journal
- Synthesis
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1055/a-2642-4294
- Primary Topic
- Innovative Microfluidic and Catalytic Techniques Innovation
- Type
- article
- Field-Weighted Citation Impact
- 0.00