Unravelling the multifaceted actions of neurosteroids: Machine learning and in vitro screening for novel target discovery
NS compounds are ascendant treatments in neuropsychiatry, but their full spectrum of actions remains unclear. This virtual and biological screening discovery approach opens new vistas for exploring the mechanism of NS analogues. The multifaceted approach provides an unbiased, holistic exploration of the potential effects of NS compounds across various molecular targets and provides a platform for future validation studies to aid drug discovery.
Authors
- Ajeet Kumar (ORCID: https://orcid.org/0000-0002-8818-3539)
- Steven Mennerick (ORCID: https://orcid.org/0000-0003-0868-0664)
- Ann Benz
- Douglas F. Covey (ORCID: https://orcid.org/0000-0002-9316-8683)
- Yuanjian Xu
- Mingxing Qian (ORCID: https://orcid.org/0000-0002-2106-2855)
- Charles F. Zorumski
Institutions
- Washington University in St. Louis (US)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1111/bph.70114
- Citations
- 1
- Primary Topic
- Receptor Mechanisms and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Institute of Mental Health
- Taylor Family Institute for Innovative Psychiatric Research, Washington University School of Medicine in St. Louis