The C-Terminal Kinase Domain–Binding and Suppression Motif Prevents Constitutive Activation of FGFR2

A C-terminal phenylalanine-serine motif suppresses FGFR2 kinase activity by mediating binding of the C-terminal tail to the kinase domain, explaining how C-terminal truncation activates FGFR2 to promote tumorigenesis.

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Publication Details

Journal
Cancer Research
Published
2025-06-24
DOI
https://doi.org/10.1158/0008-5472.can-24-3349
Citations
2
Primary Topic
Fibroblast Growth Factor Research
Type
article
Field-Weighted Citation Impact
1.61
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The C-Terminal Kinase Domain–Binding and Suppression Motif Prevents Constitutive Activation of FGFR2

Marieke van de Ven, Maarten Altelaar, Xue Chao, Chi‐Chuan Lin et al.
2 citations
Cancer Research
Fibroblast Growth Factor Research
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article

The C-Terminal Kinase Domain–Binding and Suppression Motif Prevents Constitutive Activation of FGFR2

Marieke van de Ven, Maarten Altelaar, Xue Chao, Chi‐Chuan Lin, Lodewyk F.A. Wessels, Daniel Zingg, Sjoerd Klarenbeek, Jinhyuk Bhin, Sjors M. Kas, Ellen Wientjens, Anne Paulien Drenth, John E. Ladbury, Jos Jonkers, Giulia Zanetti, Onno B. Bleijerveld, Eline van der Burg, Łukasz Wieteska, Julia Yemelyanenko, Bjørn Siteur, Stefano Annunziato, Catrin Lutz
article en
2 citations

Abstract

A C-terminal phenylalanine-serine motif suppresses FGFR2 kinase activity by mediating binding of the C-terminal tail to the kinase domain, explaining how C-terminal truncation activates FGFR2 to promote tumorigenesis.

Cancer ResearchVol. 85(17)
University of Leeds (GB), Sun Yat-sen University (CN), University of Pittsburgh (US), Utrecht University (NL), Yonsei University (KR), Dutch Cancer Society (NL), Discovery Centre (CA), The Francis Crick Institute (GB), The Netherlands Cancer Institute (NL), Oncode Institute (NL), Royal GD (Netherlands) (NL), Netherlands Comprehensive Cancer Organisation (NL), Gangnam Severance Hospital (KR), Sun Yat-sen University Cancer Center (CN)
Good health and well-being
Openalex Percentile: Top 16%
Fibroblast Growth Factor Research
1.61
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