The C-Terminal Kinase Domain–Binding and Suppression Motif Prevents Constitutive Activation of FGFR2
A C-terminal phenylalanine-serine motif suppresses FGFR2 kinase activity by mediating binding of the C-terminal tail to the kinase domain, explaining how C-terminal truncation activates FGFR2 to promote tumorigenesis.
Authors
- Marieke van de Ven (ORCID: https://orcid.org/0000-0001-6779-9353)
- Maarten Altelaar (ORCID: https://orcid.org/0000-0001-5093-5945)
- Xue Chao (ORCID: https://orcid.org/0000-0002-2784-9384)
- Chi‐Chuan Lin (ORCID: https://orcid.org/0000-0003-3071-172X)
- Lodewyk F.A. Wessels (ORCID: https://orcid.org/0000-0002-1656-6995)
- Daniel Zingg (ORCID: https://orcid.org/0000-0001-6450-2534)
- Sjoerd Klarenbeek (ORCID: https://orcid.org/0000-0002-1891-1940)
- Jinhyuk Bhin (ORCID: https://orcid.org/0000-0001-8898-4531)
- Sjors M. Kas (ORCID: https://orcid.org/0009-0007-7755-4772)
- Ellen Wientjens
- Anne Paulien Drenth
- John E. Ladbury (ORCID: https://orcid.org/0000-0002-6328-7200)
- Jos Jonkers (ORCID: https://orcid.org/0000-0002-9264-9792)
- Giulia Zanetti (ORCID: https://orcid.org/0009-0004-1526-6060)
- Onno B. Bleijerveld (ORCID: https://orcid.org/0000-0002-9395-2347)
- Eline van der Burg
- Łukasz Wieteska (ORCID: https://orcid.org/0000-0002-5890-6513)
- Julia Yemelyanenko (ORCID: https://orcid.org/0000-0001-9697-2039)
- Bjørn Siteur (ORCID: https://orcid.org/0000-0002-0213-8797)
- Stefano Annunziato (ORCID: https://orcid.org/0009-0009-7268-2788)
- Catrin Lutz (ORCID: https://orcid.org/0009-0002-5152-6785)
Institutions
- University of Leeds (GB)
- Sun Yat-sen University (CN)
- University of Pittsburgh (US)
- Utrecht University (NL)
- Yonsei University (KR)
- Dutch Cancer Society (NL)
- Discovery Centre (CA)
- The Francis Crick Institute (GB)
- The Netherlands Cancer Institute (NL)
- Oncode Institute (NL)
- Royal GD (Netherlands) (NL)
- Netherlands Comprehensive Cancer Organisation (NL)
- Gangnam Severance Hospital (KR)
- Sun Yat-sen University Cancer Center (CN)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1158/0008-5472.can-24-3349
- Citations
- 2
- Primary Topic
- Fibroblast Growth Factor Research
- Type
- article
- Field-Weighted Citation Impact
- 1.61