Immunotherapy as rescue for cardiomyopathy in Omenn syndrome

Omenn syndrome is a severe autosomal recessive combined immunodeficiency whose only curative treatment is allogeneic stem cell transplantation. We describe a rare case of infiltrative cardiomyopathy secondary to Omenn syndrome successfully treated by a combination of anti-IL5 antibodies and alemtuzumab, allowing successful HSCT.

Authors

Montserrat Sierra‐Colomina (ORCID: https://orcid.org/0000-0001-5714-9357)
Lionel Berthomieu (ORCID: https://orcid.org/0009-0005-5661-5965)
Marlène Pasquet (ORCID: https://orcid.org/0000-0001-6919-8383)
Vincent Barlogis (ORCID: https://orcid.org/0000-0001-9645-3968)
Simon Boutinaud

Institutions

Inserm (FR)
Université Fédérale de Toulouse Midi-Pyrénées (FR)
Centre Hospitalier Universitaire de Toulouse (FR)
Assistance Publique Hôpitaux de Marseille (FR)
Centre de Recherches en Cancérologie de Toulouse (FR)

Publication Details

Journal: Journal of Human Immunity
Published: 2025-05-31
DOI: https://doi.org/10.70962/jhi.20250046
Primary Topic: Eosinophilic Disorders and Syndromes
Type: article
Field-Weighted Citation Impact: 0.00

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article

Immunotherapy as rescue for cardiomyopathy in Omenn syndrome

Montserrat Sierra‐Colomina, Lionel Berthomieu, Marlène Pasquet, Vincent Barlogis et al.

May 31, 2025

Journal of Human Immunity

Eosinophilic Disorders and Syndromes

article

Immunotherapy as rescue for cardiomyopathy in Omenn syndrome

Montserrat Sierra‐Colomina, Lionel Berthomieu, Marlène Pasquet, Vincent Barlogis, Simon Boutinaud

May 31, 2025article en

Abstract

Omenn syndrome is a severe autosomal recessive combined immunodeficiency whose only curative treatment is allogeneic stem cell transplantation. We describe a rare case of infiltrative cardiomyopathy secondary to Omenn syndrome successfully treated by a combination of anti-IL5 antibodies and alemtuzumab, allowing successful HSCT.

Journal of Human ImmunityVol. 1(3)

Inserm (FR), Université Fédérale de Toulouse Midi-Pyrénées (FR), Centre Hospitalier Universitaire de Toulouse (FR), Assistance Publique Hôpitaux de Marseille (FR), Centre de Recherches en Cancérologie de Toulouse (FR)

Openalex Percentile: Top 76%

Eosinophilic Disorders and Syndromes

DOI Open Access PDF OpenAlex

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