Genomic Deletion of PfHRP2 and PfHRP3 Antigens in <i>Plasmodium falciparum</i> Strains, Ethiopia, 2009
Plasmodium falciparum strains lacking P. falciparum histidine-rich protein 2 (PfHRP2) and PfHRP3 threaten malaria rapid test reliability. We show that pfhrp2/pfhrp3-deleted parasites circulated in Ethiopia as early as 2009, before widespread PfHRP2-based rapid test use, and had high pfhrp3 deletion prevalence. Monitoring of pfhrp2 and of pfhrp3 deletions is needed.
Authors
- Jana Held (ORCID: https://orcid.org/0000-0002-7970-1429)
- Sabine Bélard (ORCID: https://orcid.org/0000-0002-2008-418X)
- Andrea Kreidenweiss (ORCID: https://orcid.org/0000-0002-5025-7221)
- Sindew Mekasha Feleke (ORCID: https://orcid.org/0000-0002-5778-653X)
- Torsten Krüger
- Peter G. Kremsner (ORCID: https://orcid.org/0000-0002-3926-4113)
- Hassen Mamo (ORCID: https://orcid.org/0000-0001-9541-8976)
- Tesfaye Gelanew (ORCID: https://orcid.org/0000-0002-0696-3786)
- Miriam Rodi
- Tamirat Gebru Woldearegai (ORCID: https://orcid.org/0000-0001-9508-1787)
- Vanessa Krohmer
Publication Details
- Journal
- Emerging infectious diseases
- Published
- 2025-06-24
- DOI
- https://doi.org/10.3201/eid3107.241676
- Primary Topic
- Blood groups and transfusion
- Type
- article
- Field-Weighted Citation Impact
- 0.00