Microwave-Assisted Intramolecular Dehydrogenative Coupling Reaction: Access to γ-Carboline Derivatives
A microwave-assisted intramolecular dehydrogenative coupling reaction for the construction of novel γ-carbolines was established. Following Pd(II)/Cu(II)-catalyzed C-H activation, intramolecular cyclization provided γ-carbinone derivatives with various substituents in 57-85% yield. The rapid synthesis of γ-carbolines and wide functional group tolerance are among the advantages of this microwave-assisted approach.
Authors
- Xiang Zhou (ORCID: https://orcid.org/0000-0002-1973-3736)
- Lifeng Jiang
- Chunmei Li (ORCID: https://orcid.org/0000-0001-8843-0627)
- Furen Zhang (ORCID: https://orcid.org/0000-0002-7361-9475)
Institutions
- Shaoxing University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1021/acs.joc.5c00966
- Citations
- 3
- Primary Topic
- Asymmetric Hydrogenation and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China