Reemergence of Human Rabies in an Endemic Peruvian Amazon Region

We report the case of two girls from a rural community in the Peruvian Amazon who were exposed to the rabies virus, with fatal outcomes in both cases. The reemergence of rabies in this endemic area after more than 11 years of successful control through massive immunization policies is highlighted in this report. In these cases, exposure occurred through contact with a domestic cat, although bat bites remain the most common source of rabies transmission in the region. Adopting a One Health approach and reinforcing periodic mass immunization campaigns are essential to prevent further outbreaks in endemic rabies zones.