Reimagining Neuropsychiatric and Neurological Disorders through the Lens of Brain Network Dynamics: Psychedelics as Catalysts for System-Level Plasticity
Neuropsychiatric disorders reflect disruptions in brain network dynamics along an "order-complexity-chaos" continuum. Psychedelics may therapeutically increase neural entropy, disrupt maladaptive patterns, and promote network reorganization. This system-level framework emphasizes dynamic connectome remodeling over static molecular correction, offering a novel strategy for treating psychiatric and neurological conditions through controlled neural destabilization and reconnection.
Authors
- Yibo Wang
- Cong Zhang (ORCID: https://orcid.org/0009-0000-5403-2866)
- Xiaohui Wang (ORCID: https://orcid.org/0000-0002-3415-5612)
Institutions
- University of Science and Technology of China (CN)
- Chinese Academy of Sciences (CN)
- Changchun Institute of Applied Chemistry (CN)
- NOAA Chemical Sciences Laboratory (US)
- Zhejiang University (CN)
Publication Details
- Journal
- ACS Pharmacology & Translational Science
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1021/acsptsci.5c00379
- Citations
- 2
- Primary Topic
- Psychedelics and Drug Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.61
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- Zhejiang University
- National Key Research and Development Program of China