Increased platelet activation and thrombo-inflammation in early and late-onset preeclampsia
These findings identify that thrombo-inflammation is regulated in L-PE and E-PE through likely disjunct mechanisms supporting a role of maternal factors (eg, maternal platelet activation) involved in L-PE. Further studies with a larger cohort of patients are required to fully elucidate the mechanistic relevance of these findings.
Authors
- Berend Isermann
- Martin Federbusch (ORCID: https://orcid.org/0000-0002-1126-5763)
- Kunal Kumar Singh (ORCID: https://orcid.org/0000-0003-1026-1282)
- Holger Stepan (ORCID: https://orcid.org/0000-0003-1264-7365)
- Ahmed Elwakiel (ORCID: https://orcid.org/0000-0001-6784-8370)
- Massimiliano Lia (ORCID: https://orcid.org/0000-0001-8285-3792)
- Shrey Kohli (ORCID: https://orcid.org/0000-0003-2118-7380)
- Moritz Köhler
- Akshay Prakasan Sheeja
- Anubhuti Gupta
Institutions
- Leipzig University of Applied Sciences (DE)
- University Hospital Leipzig (DE)
- Leipzig University (DE)
Publication Details
- Journal
- Research and Practice in Thrombosis and Haemostasis
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1016/j.rpth.2025.102956
- Citations
- 3
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 6.17
Funders
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung