Novel Potential Probiotics from Chinese Baijiu Fermentation Grains: Dual Action of Lactiplantibacillus plantarum LTJ1/LTJ48 in Uric Acid Reduction and Gut Microbiota Restoration for Hyperuricemia Therapy in Mice
LTJ1/LTJ48 exhibit multi-target HUA alleviation via purine degradation, ADA inhibition, UA transporter regulation, and microbiota remodeling, offering a safer probiotic-based alternative to conventional therapies. Their translational potential warrants further clinical exploration.
Authors
- Xuegang Luo (ORCID: https://orcid.org/0000-0002-7975-0722)
- Jianxia Tian
- Jun Cao (ORCID: https://orcid.org/0000-0002-3899-4878)
- Feiliang Zhong
- Jiali Wang (ORCID: https://orcid.org/0000-0001-5335-3000)
- Xiaomin Feng (ORCID: https://orcid.org/0009-0007-2212-5268)
- Miao Li (ORCID: https://orcid.org/0000-0002-4360-1960)
- Xuefang Wang (ORCID: https://orcid.org/0000-0001-7955-8776)
Institutions
- Tianjin University of Science and Technology (CN)
Publication Details
- Journal
- Nutrients
- Published
- 2025-06-24
- DOI
- https://doi.org/10.3390/nu17132097
- Citations
- 3
- Primary Topic
- Gout, Hyperuricemia, Uric Acid
- Type
- article
- Field-Weighted Citation Impact
- 4.29
Funders
- Centre Scientifique et Technique du Bâtiment
- National Key Research and Development Program of China