Endothelial HOXB9/SDC4 signaling exacerbates post-ischemic blood-brain and blood-spinal cord barrier disruption by promoting PKCα activation
HOXB9 interference inhibited SDC4 transcription to attenuate PKCα activation, finally alleviate BBB disruption, spinal cord injury and BSCB damage.
Authors
- Yue-Hui Ma
- Xiaoyi Wang (ORCID: https://orcid.org/0000-0001-7748-2296)
- Zuoxu Fan
- Liqing Wang (ORCID: https://orcid.org/0000-0002-4240-0569)
- Hengjun Zhou (ORCID: https://orcid.org/0000-0002-3661-8959)
- Jie-Sheng Zheng (ORCID: https://orcid.org/0000-0002-9027-4018)
Institutions
- First Affiliated Hospital Zhejiang University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Brain Research Bulletin
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1016/j.brainresbull.2025.111441
- Citations
- 3
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 4.88
Funders
- National Natural Science Foundation of China