A new pathway for neuroprotection against tau hyperphosphorylation via δ-opioid receptor initiated inhibition of CDK5 and AMPK signaling
Our novel findings suggest that DOR signaling may protect neurons from AD injury by inhibiting tau hyperphosphorylation.
Authors
- Yuan Xu (ORCID: https://orcid.org/0000-0003-1093-9428)
- Ying Xia (ORCID: https://orcid.org/0000-0002-0126-6594)
- Gianfranco Balboni (ORCID: https://orcid.org/0000-0003-4437-6096)
- Jiahui Li (ORCID: https://orcid.org/0000-0003-4817-220X)
Institutions
- University of Cagliari (IT)
- Fudan University (CN)
- Soochow University (CN)
- The First People's Hospital of Changzhou (CN)
- Shanghai Research Center for Acupuncture and Meridians (CN)
- Nanjing University of Aeronautics and Astronautics (CN)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-06-24
- DOI
- https://doi.org/10.3389/fnagi.2025.1587219
- Citations
- 1
- Primary Topic
- Metabolism, Diabetes, and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality