Rats subject to extracorporeal membrane oxygenation have improved cardiac function following anticoagulation and reversal with factor IXa aptamer-antidote oligonucleotide pair
The antidote-controlled anti-FIXa aptamer represents an alternative anticoagulant strategy that may prove useful for managing patients with a history of heparin-induced thrombocytopenia (HIT) and myocardial dysfunction associated with protamine administration.
Authors
- George A. Pitoc
- Shahid M. Nimjee (ORCID: https://orcid.org/0000-0002-0317-8731)
- Bruce A. Sullenger (ORCID: https://orcid.org/0000-0002-5113-5541)
- Fellery de Lange
Institutions
- Duke Medical Center (US)
- Duke University Hospital (US)
Publication Details
- Journal
- Cardiology Plus
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1097/cp9.0000000000000122
- Citations
- 1
- Primary Topic
- Heparin-Induced Thrombocytopenia and Thrombosis
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- National Institutes of Health