Aspergillary Infections in Immunocompromised Patients in the Parasitology Department of Chu Mohamed VI de Marrakech 23 Cases

This retrospective study analyzed the records of 23 immunocompromised patients with aspergillosis at CHU Mohamed VI in Marrakech between January 2022 and June 2024. The main risk factors were diabetes (43.5%) and HIV infection (26%). Samples were taken in different hospital departments, with a predominance of dermatology (39%) and infectious diseases/hematology (17%). The samples were directly examined by optical microscopy after MGG staining, and then cultured on Sabouraud medium at 30-35°C for 30 days. The identification of species was based on macroscopic and microscopic features of colonies. Galactomannan antigen assay was performed when requested by clinicians. The results show a male predominance (sex-ratio 3.2) with an average age of 50 years. A. fumigatus was the most common species (48%), followed by A. flavus (35%) and A. niger (17%). The majority of samples were superficial mycoses (74%). This study highlights the importance of aspergillary infections in immunocompromised people in Morocco and underlines the need for early diagnosis combining mycological examinations and antigen detection. Limitations include small size and retrospective nature, justifying additional studies.