Reliable monitoring of respiratory function with home spirometry in people living with amyotrophic lateral sclerosis
The observed linearity in respiratory trajectories supports the potential for early and accurate estimation of progression, reinforcing the feasibility of less frequent monitoring without compromising assessment precision and reducing the burden on both pALS and the healthcare system. Furthermore, our results align with reported in-clinic pulmonary tests, validating remote monitoring as a means to promote more equitable and accessible clinical trial designs.
Authors
- Oren Levy (ORCID: https://orcid.org/0000-0002-9146-821X)
- Terry Heiman‐Patterson (ORCID: https://orcid.org/0000-0002-9910-1041)
- Matthew F. Wipperman (ORCID: https://orcid.org/0000-0003-1436-3366)
- Marcos A. Trevisan (ORCID: https://orcid.org/0000-0003-4698-9224)
- Lyle W. Ostrow (ORCID: https://orcid.org/0000-0001-7158-5243)
- Karl Sillay
- Diego E. Shalóm (ORCID: https://orcid.org/0000-0002-1648-149X)
- James D. Berry (ORCID: https://orcid.org/0000-0003-0898-6081)
- Ernest Fraenkel (ORCID: https://orcid.org/0000-0001-9249-8181)
- Jason Osik
- Alan Taitz (ORCID: https://orcid.org/0000-0003-4249-7521)
- Peng Jiang (ORCID: https://orcid.org/0000-0002-6057-7624)
- Michael Sherman
- Joel Schwartz
- Indu Navar Bingham
- Julián Peller
- Esteban G. Roitberg
- Felipe Aguirre (ORCID: https://orcid.org/0000-0001-8768-4780)
- Guofa Shou
- Ryan A. Shewcraft
- Gaston Bujia
- Stephanie Henze
- Silviya Bastola
Institutions
- Eli Lilly (United States) (US)
- Regeneron (United States) (US)
- National University of General San Martín (AR)
- Massachusetts General Hospital (US)
- Bristol-Myers Squibb (United States) (US)
- EvergreenHealth Foundation (US)
- Fundación Ciencias Exactas y Naturales (AR)
- Massachusetts Institute of Technology (US)
- Drexel University (US)
- Temple University (US)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2025-06-24
- DOI
- https://doi.org/10.3389/fneur.2025.1588992
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bristol-Myers Squibb