FGF10 Protects the Corneal Epithelium From Dry Eye-Induced Oxidative and ER Stress Via Upregulation of SLC7A11
FGF10 protects mouse corneal epithelium and HCE-2 cells from oxidative stress, ER stress, and apoptosis, partially through SLC7A11 upregulation. The FGF10-SLC7A11 pathway represents a promising therapeutic target in dry eye.
Authors
- Zhiwei Zha
- Wei Chen (ORCID: https://orcid.org/0000-0002-2339-5741)
- Yang Liu
- Haiyuan Chang
- Juan Li (ORCID: https://orcid.org/0000-0001-8320-2406)
- Xu Shang
- Shuang Xie (ORCID: https://orcid.org/0000-0003-4759-4160)
- Zilan Xu (ORCID: https://orcid.org/0009-0006-0915-8076)
- Kaisheng Wang (ORCID: https://orcid.org/0000-0001-5039-2098)
Institutions
- Wenzhou Medical University (CN)
- Wuhan University (CN)
- Affiliated Eye Hospital of Wenzhou Medical College (CN)
- Zhongnan Hospital of Wuhan University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1167/iovs.66.6.72
- Citations
- 2
- Primary Topic
- Ocular Surface and Contact Lens
- Type
- article
- Field-Weighted Citation Impact
- 3.76