Investigation of Antiproliferative Effects of Heracleum persicum Extracts on Glioblastoma Multiforme Cell Line

Heracleum persicum (H. percium) is a plant known for its anti-inflammatory, analgesic, anticonvulsant, and antioxidant properties. In this study, the antiproliferative effects of the ethanolic leaf and root extracts of the plant on the human Glioblastoma Multiforme U-87MG cell line were evaluated. The leaf and root extracts were applied at concentrations of 10⁻¹, 10⁻², 10⁻³, 10⁻⁴, 10⁻⁵, and 10⁻⁶ mg/mL for 24 and 72 hours, and cell viability was determined using the MTT assay. The results showed that at a concentration of 10⁻¹ mg/mL for 24 hours, the leaf and root extracts caused cell death at rates of 76% and 81%, respectively. In the 72-hour application, the leaf extract at a concentration of 10⁻¹ mg/mL led to 83% cell death, while the root extract at the same concentration caused 92% cell death. These findings demonstrate that H. persicum extracts exhibit antiproliferative effects on the U-87MG cell line and suggest their potential as therapeutic agents.