Expression Dynamics and Estrogen Response of Estrogen Receptors in Duolang Sheep During Puberty
These findings suggest that ERα primarily mediates E2 feedback within the hypothalamus-pituitary axis, whereas ERβ is associated with ovarian development and may regulate GnRH expression during the pubertal transition. The study provides new insights into the hormonal regulation of puberty in Duolang sheep and offers potential biomarkers for improving reproductive efficiency through targeted breeding strategies.
Authors
- Lihui Zhu (ORCID: https://orcid.org/0000-0002-2931-6207)
- Jihu Zhang (ORCID: https://orcid.org/0000-0002-2802-8588)
- Ruimin Gu (ORCID: https://orcid.org/0009-0006-4447-3178)
- Feng Xing
- Huiping Sun (ORCID: https://orcid.org/0009-0004-5545-6344)
- Wei Li (ORCID: https://orcid.org/0000-0003-4464-2446)
- Gul Muhammad Shahbaz (ORCID: https://orcid.org/0009-0008-0886-8863)
Institutions
- Xinjiang Production and Construction Corps (CN)
- Tarim University (CN)
Publication Details
- Journal
- Genes
- Published
- 2025-06-24
- DOI
- https://doi.org/10.3390/genes16070731
- Primary Topic
- Estrogen and related hormone effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China