Evidence that hPIV2 paramyxovirus antigenomes are edited during infection
We have assumed that paramyxovirus editing signals would operate strictly during mRNA synthesis, as it apparently makes no sense to edit antigenomes. Nevertheless, there is evidence here that the opposite is the case. If so, this alters our view of paramyxovirus replication, and we summarize what is known about how its RNA-dependent RNA polymerase carries out its task of expressing alternate open reading frames during mRNA synthesis.
Authors
- Machiko Nishio (ORCID: https://orcid.org/0000-0002-5311-5798)
- Yusuke Matsumoto (ORCID: https://orcid.org/0000-0003-3500-2279)
- Daniel Kolakofsky (ORCID: https://orcid.org/0000-0002-3451-4697)
- Junna Kawasaki (ORCID: https://orcid.org/0000-0002-6609-5300)
- Keisuke Ohta (ORCID: https://orcid.org/0000-0003-4317-7407)
Institutions
- Kagoshima University (JP)
- University of Geneva (CH)
- Chiba University (JP)
- Wakayama Medical University (JP)
Publication Details
- Journal
- mBio
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1128/mbio.03667-24
- Primary Topic
- Virology and Viral Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Takeda Science Foundation
- Japan Agency for Medical Research and Development
- Kato Memorial Bioscience Foundation
- Kieikai Research Foundation