CypA inhibits respiratory syncytial virus (RSV) replication by suppressing glycolysis through the downregulation of PKM2 expression
Viruses utilize the host's resources and energy to carry out essential life processes and achieve self-replication. In response, hosts have evolved a range of antagonistic mechanisms. Our study investigates how RSV employs glycolysis to benefit its replication, with a particular focus on the interaction between glycolysis and IFNβ regulation. Additionally, we explore how the host employs CypA to antagonize the virus's utilization of glycolysis, thereby inhibiting RSV replication. Our findings will contribute to the development of effective antiviral therapies targeting CypA.
Authors
- Jiachao Wang
- Wenzhang Liang (ORCID: https://orcid.org/0000-0002-8832-0150)
- Miao Li (ORCID: https://orcid.org/0009-0004-8775-686X)
- Yutong Wang (ORCID: https://orcid.org/0000-0001-8943-1832)
- Jing Cheng (ORCID: https://orcid.org/0000-0002-6145-1003)
- Lizheng Yin
- Jing Zhang (ORCID: https://orcid.org/0000-0002-0784-0956)
- Lin Wei (ORCID: https://orcid.org/0000-0002-3265-3554)
- Xue Gao (ORCID: https://orcid.org/0000-0003-4805-6081)
- Cuiqing Ma (ORCID: https://orcid.org/0000-0001-9021-7040)
Institutions
- Hebei Medical University (CN)
- Hebei University of Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Virology
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1128/jvi.00074-25
- Citations
- 1
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 1.35