Cell death-inducing DFF45-like effector C intervenes the progression of nonsmall-cell lung cancer via modulating lipid metabolism
This study is the first to establish a link between CIDEC expression and lipid droplet lipolysis in NSCLC. Our findings indicate that CIDEC plays a critical role in regulating lipid metabolism and tumor progression in lung cancer. The downregulation of CIDEC in NSCLC promotes tumorigenesis by enhancing ATGL-induced lipolysis, highlighting CIDEC as a potential therapeutic target for lung cancer through metabolic reprogramming of lipid droplets. These insights provide a novel direction for targeted treatment strategies in NSCLC.
Authors
- Jinshi Huang (ORCID: https://orcid.org/0000-0003-2857-632X)
- Q. B. Yi (ORCID: https://orcid.org/0009-0001-7168-3481)
- Jiaxin Ye (ORCID: https://orcid.org/0000-0002-8448-4166)
- Lingyan Gong (ORCID: https://orcid.org/0009-0007-6974-9609)
- Yingfang Sun
- Liu Liu (ORCID: https://orcid.org/0000-0003-3566-0212)
- Yuqing Chen (ORCID: https://orcid.org/0000-0001-5850-1826)
- Jun Ni (ORCID: https://orcid.org/0000-0003-1487-2574)
- Xiaoyu Zhou (ORCID: https://orcid.org/0000-0002-4657-0418)
- W. Zou
Institutions
- Fujian Medical University (CN)
- Nantong University (CN)
- Affiliated Hospital of Nantong University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1097/js9.0000000000002796
- Citations
- 2
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.87