CD317 functions as a key antiviral factor in human herpesvirus 6 (HHV-6) infection
Upon stimulation with type I interferon, hundreds of interferon-stimulated genes (ISGs) are induced to express. For an individual virus, it is crucial to identify and analyze the key ISGs. Here, we discovered that CD317 is one of the key ISGs that restrict HHV-6 infection. While CD317 is well known for its ability to inhibit the release of progeny virions, we have revealed a novel role for CD317 in restricting HHV-6 infection by inhibiting viral entry. Additionally, we found that CD317 interacts with HHV-6 glycoprotein O (gO), a protein of unknown function, leading to the proteasomal degradation of gO. This finding may provide valuable clues for further analysis of gO's function.
Authors
- Xianyi Xu
- Junli Jia (ORCID: https://orcid.org/0009-0002-2945-1107)
- Jingjing Ma (ORCID: https://orcid.org/0000-0002-2548-5871)
- Lingyun Li (ORCID: https://orcid.org/0000-0001-9569-9966)
- Huamin Tang (ORCID: https://orcid.org/0000-0002-5724-3973)
- Shuhua Chen (ORCID: https://orcid.org/0000-0002-9178-5020)
- Xin Zhang (ORCID: https://orcid.org/0000-0003-0201-0117)
- Minmin Song
- Hua Xie
Institutions
- Jiangsu University (CN)
- Jintan People's Hospital (CN)
- Second Affiliated Hospital of Nanjing Medical University (CN)
- Hangzhou Cancer Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Journal of Virology
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1128/jvi.00841-25
- Primary Topic
- Cytomegalovirus and herpesvirus research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangsu Province