Ghrelin ameliorates sepsis-induced acute skeletal muscle wasting via hypothalamic JAK2/STAT3-AgRP pathway
Ghrelin could regulate sepsis-induced acute skeletal muscle wasting via hypothalamic JAK2/STAT3 and AgRP pathway. The protective effect of EN on muscle wasting was mediated by ghrelin and AgRP.
Authors
- Lixing Gu
- Xiaotong Sun (ORCID: https://orcid.org/0000-0001-5628-0994)
- Kaipeng Duan
- Xinyan Gao (ORCID: https://orcid.org/0000-0002-6569-7510)
- Tao Chen (ORCID: https://orcid.org/0000-0002-9786-9292)
- Jin Zhou (ORCID: https://orcid.org/0000-0001-8121-4198)
- Dongbao Li (ORCID: https://orcid.org/0000-0002-2905-9079)
- Pengbo Wang (ORCID: https://orcid.org/0000-0001-7405-7905)
- Weikang Li (ORCID: https://orcid.org/0009-0003-6715-3247)
Institutions
- Soochow University (CN)
- First Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-06-20
- DOI
- https://doi.org/10.1097/js9.0000000000002724
- Citations
- 2
- Primary Topic
- Adipokines, Inflammation, and Metabolic Diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.71