CircASH1L inhibits ferroptosis and enhances cisplatin resistance by sponging miR-515-5p to regulate cell cycle-related CDCA7/RRM2 in ovarian cancer cells
Our study demonstrates that silencing circASH1L alleviates cisplatin resistance in ovarian cancer cells. The underlying mechanism involves the upregulation of miR-515-5p, which targets the CDCA7/RRM2 axis, leading to cell cycle modulation and the induction of ferroptosis. Targeting the circASH1L/miR-515-5p/CDCA7 pathway offers new insights into the relationship between ferroptosis and chemoresistance, presenting a promising strategy to overcome chemoresistance in ovarian cancer.
Authors
- Ying Tang (ORCID: https://orcid.org/0000-0002-9526-9613)
- Tianwen He
- Feng Gui Lu (ORCID: https://orcid.org/0000-0001-9064-7964)
- Xinru Zou
- Yijun Yuan
- Bin Su (ORCID: https://orcid.org/0000-0002-0711-441X)
- Kang Liu (ORCID: https://orcid.org/0000-0002-1012-7190)
- Jiang Wang (ORCID: https://orcid.org/0009-0008-9688-4416)
- Linlin Tang (ORCID: https://orcid.org/0000-0002-6337-4363)
- Jun Li (ORCID: https://orcid.org/0009-0004-1683-5130)
Institutions
- North Sichuan Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-06-24
- DOI
- https://doi.org/10.3389/fphar.2025.1563869
- Citations
- 1
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.81