Correlation between treatments and outcomes of patients with EGFR-mutated non-small-cell lung cancer that transitioned into small-cell lung cancer: an international retrospective study
The prognosis of patients with transformed SCLC remains poor, with only a minority achieving meaningful survival. Survival was similar in patients treated with CT alone or with the addition of ICI or EGFR-TKI. A time interval >12 months between NSCLC diagnosis and SCLC transformation was associated with longer survival and may reflect a different biology than early transformation.
Authors
- Stefania Martini (ORCID: https://orcid.org/0000-0002-0686-6775)
- Alessandro Russo (ORCID: https://orcid.org/0000-0002-3365-1972)
- Giuliana Muti
- Vieri Scotti (ORCID: https://orcid.org/0000-0002-1498-7171)
- Priscilla Cascetta (ORCID: https://orcid.org/0000-0002-4252-7543)
- A. Delmonte
- F. Citarella
- Stephen V. Liu (ORCID: https://orcid.org/0000-0002-4852-3914)
- Emanuela Olmetto
- Chiara Bennati (ORCID: https://orcid.org/0000-0002-2970-6483)
- Marco Russano
- A. Esposito (ORCID: https://orcid.org/0000-0003-0664-3122)
- Ida Colantonio
- Tommaso De Pas (ORCID: https://orcid.org/0000-0001-5684-5254)
- Miguel Agüero Pino
- C. Genova
- F. Cappuzzo
- Laura Pala (ORCID: https://orcid.org/0000-0002-0111-9869)
- Fabio Conforti (ORCID: https://orcid.org/0000-0002-6233-0502)
- Marina Chiara Garassino (ORCID: https://orcid.org/0000-0002-3821-5598)
- Chiara Catania (ORCID: https://orcid.org/0009-0008-2926-4663)
- Anna Di Lello
Institutions
- Humanitas University (IT)
- Vita-Salute San Raffaele University (IT)
- Georgetown University (US)
- University of Catania (IT)
- University of Chicago (US)
- Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IT)
- Azienda Unità Sanitaria Locale Della Romagna (IT)
- Azienda Ospedaliero-Universitaria Careggi (IT)
- Humanitas Gavazzeni (IT)
- Azienda Sanitaria Ospedaliera S.Croce e Carle Cuneo (IT)
- Campus Bio Medico University Hospital (IT)
- Tumori Foundation (US)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
Publication Details
- Journal
- ESMO Open
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1016/j.esmoop.2025.105326
- Citations
- 6
- Primary Topic
- Lung Cancer Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 6.27