Uncovering Novel lncRNAs Linked to Melanoma Growth and Migration with CRISPR Inhibition Screening
LncRNAs have emerged as novel players in regulating many cellular aspects also in melanoma. The number of functional significances of most lncRNAs remains elusive. We provide a comprehensive strategy to identify functionally relevant lncRNAs in melanoma by combining expression profiling with CRISPR inhibition growths screens. Our results broaden the characterized lncRNAs as potential targets for future therapeutic applications.
Authors
- Seyedeh Elnaz Banijamali (ORCID: https://orcid.org/0000-0003-4718-9720)
- Stavroula Petroulia (ORCID: https://orcid.org/0009-0007-1348-8315)
- Palaniraja Thandapani (ORCID: https://orcid.org/0000-0002-9881-3645)
- Kathryn Hockemeyer (ORCID: https://orcid.org/0000-0002-3942-3129)
- Jochen Imig (ORCID: https://orcid.org/0000-0003-0385-1081)
- Jeffrey L. Schloßhauer (ORCID: https://orcid.org/0009-0000-2583-3445)
- Aristotelis Tsirigos (ORCID: https://orcid.org/0000-0002-7512-8477)
- Eleazar Vega‐Saenz de Miera (ORCID: https://orcid.org/0000-0001-8443-1286)
- Iman Osman (ORCID: https://orcid.org/0000-0002-1472-1971)
- Iannis Aifantis (ORCID: https://orcid.org/0000-0001-6857-1035)
- Pietro Berico (ORCID: https://orcid.org/0000-0001-8034-0790)
- Yixiao Gong (ORCID: https://orcid.org/0000-0002-3462-9734)
- Sama Shamloo
- Eric Wang (ORCID: https://orcid.org/0000-0001-7865-6702)
- Sudhanshu Tiwari
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- NYU Langone Health (US)
- Jackson Laboratory (US)
- Max Planck Institute of Molecular Physiology (DE)
- Chemical Genomics Centre (DE)
- New York University (US)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1158/2767-9764.crc-24-0416
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.00