Mangiferin modulates lipid metabolism via AKR1B1 in response to advanced glycation end products
These findings establish AKR1B1 as a critical regulator of lipid metabolism in DPN and identify mangiferin as a promising therapeutic agent to inhibit AKR1B1 activity and restore lipid homeostasis in diabetic neuropathy.
Authors
- Sunil K. Manna (ORCID: https://orcid.org/0000-0002-0149-209X)
- Abhishek Aher
- Debasish Kumar Ghosh (ORCID: https://orcid.org/0000-0002-9196-0685)
- Saphy Sharda (ORCID: https://orcid.org/0000-0002-5115-2245)
Institutions
- Manipal Academy of Higher Education (IN)
- Regional Centre for Biotechnology (IN)
- Kasturba Medical College, Manipal (IN)
- Centre for DNA Fingerprinting and Diagnostics (IN)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-06-22
- DOI
- https://doi.org/10.1111/bph.70084
- Citations
- 4
- Primary Topic
- Mangiferin and Mango Extracts
- Type
- article
- Field-Weighted Citation Impact
- 9.53
Funders
- Centre for DNA Fingerprinting and Diagnostics