Formulation and Evaluation of Polyherbal Gummies for Alzheimer’s disease

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive impairment, memory loss, and behavioral disturbances. Conventional therapeutic approaches offer limited efficacy and are often associated with adverse effects, highlighting the need for safer and more effective alternatives. This study focuses on the formulation and evaluation of polyherbal gummies incorporating standardized extracts of Ashwagandha (Withania somnifera), Tulsi (Ocimum sanctum), and Turmeric (Curcuma longa), Guava leaves (Psidium guajava), selected for their well-documented antioxidant, anti-inflammatory, and neuroprotective properties. The gummies were prepared using a sugar-based soft matrix, ensuring high palatability and patient compliance, particularly in elderly populations. Standardized evaluation parameters, including organoleptic properties, weight variation, pH, texture analysis, antioxidant assays (DPPH, FRAP), acetylcholinesterase (AChE) inhibition assay, and microbial testing, were conducted to determine the quality and efficacy of the formulation. The formulated gummies showed desirable physical characteristics, acceptable taste, and uniform weight distribution. Antioxidant assays revealed significant free radical scavenging activity, with notable DPPH inhibition percentages and strong ferric reducing antioxidant power (FRAP). AChE inhibition studies indicated moderate suppression of enzymatic activity, suggesting potential cognitive enhancement and neuroprotection against Alzheimer's-related neurodegeneration. Microbial analysis confirmed the microbiological safety of the product within acceptable pharmacopeial limits.