High‐Dose Pulse Glucocorticoid Treatment Prevents White Matter Spinal Cord Pseudoatrophy in Newly Diagnosed Multiple Sclerosis
HDG preceding baseline MRI suppresses CNS white matter (WM) pseudoatrophy after DMT initiation, most conspicuously for the SC. Suppression of pseudoatrophy with HDG may improve the fidelity of clinical trials and enhance the feasibility for short-term trials with SC and brain MRI outcomes in active MS by pretreatment with HDG. ANN NEUROL 2025;98:837-850.
Authors
- Eduardo Caverzasi (ORCID: https://orcid.org/0000-0002-0350-0460)
- Simone Sacco (ORCID: https://orcid.org/0000-0001-8789-3099)
- Amit Akula (ORCID: https://orcid.org/0000-0003-2867-7569)
- Shuiting Cheng (ORCID: https://orcid.org/0000-0002-8669-7931)
- Ari Green (ORCID: https://orcid.org/0000-0001-9275-3066)
- Christian Cordano (ORCID: https://orcid.org/0000-0002-1413-0442)
- Bruce Cree (ORCID: https://orcid.org/0000-0001-7689-2533)
- Douglas S. Goodin (ORCID: https://orcid.org/0000-0002-5985-0822)
- Michael R. Wilson (ORCID: https://orcid.org/0000-0002-8705-5084)
- Scott S. Zamvil (ORCID: https://orcid.org/0000-0003-2720-9915)
- Jeremy Juwono
- Meagan Harms
- Emmanuelle L. Waubant (ORCID: https://orcid.org/0000-0001-5188-0157)
- Jeffrey Marc Gelfand (ORCID: https://orcid.org/0000-0002-5121-3319)
- W. Stern (ORCID: https://orcid.org/0000-0003-1236-7654)
- Riley M. Bove (ORCID: https://orcid.org/0000-0002-2034-8800)
- Roland G. Henry (ORCID: https://orcid.org/0000-0002-8232-7562)
- Vinícius Andreoli Schoeps (ORCID: https://orcid.org/0000-0001-8875-0567)
- Nico Papinutto (ORCID: https://orcid.org/0000-0003-2184-4782)
- Antje Bischof (ORCID: https://orcid.org/0000-0003-3862-5738)
- Refujia Gomez (ORCID: https://orcid.org/0000-0003-0730-8019)
- Alexandra Beaudry‐Richard (ORCID: https://orcid.org/0000-0002-5974-8916)
- Jorge R. Oksenberg (ORCID: https://orcid.org/0000-0002-3613-9544)
- Adam Santaniello (ORCID: https://orcid.org/0000-0002-9816-5932)
- Haojun Zhao (ORCID: https://orcid.org/0009-0003-4978-1047)
- Stephen L. Hauser (ORCID: https://orcid.org/0000-0002-4932-4001)
- Manula Dombagahawatta
Institutions
- University of Ottawa (CA)
- University of California, San Francisco (US)
- University of Pavia (IT)
- University Hospital Münster (DE)
- Ospedale Policlinico San Martino (IT)
- University of Genoa (IT)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1002/ana.27298
- Citations
- 1
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- National Multiple Sclerosis Society
- Fondazione Italiana Sclerosi Multipla
- Race to Erase MS
- Valhalla Foundation
- National Institutes of Health
- Advanced Research Projects Agency
- National Institute of Neurological Disorders and Stroke