Engineering BSA-CAT-Ir nanoparticles for enhanced sonodynamic therapy <i>via</i> alleviating tumor hypoxia
Sonodynamic therapy (SDT) has received extensive attention in tumor treatment due to its unique advantages. However, the hypoxic tumor microenvironment substantially restricts the sonodynamic effect. In this work, BSA-CAT-Ir nanoparticles were successfully developed to overcome the limitations of SDT in solid hypoxic tumors. The nanoparticles can alleviate tumor hypoxia by catalyzing the decomposition of overexpressed hydrogen peroxide in tumors to generate oxygen, thereby enhancing the efficacy of SDT. <i>In vitro</i> and <i>in vivo</i> experiments demonstrated that BSA-CAT-Ir nanoparticles significantly inhibited tumor growth under ultrasound, providing an effective strategy for tumor hypoxia modulation and SDT resistance suppression.
Authors
- Lutong Wen
- Jiaxi Ru (ORCID: https://orcid.org/0000-0002-7469-1911)
- Guosheng Song (ORCID: https://orcid.org/0000-0001-5628-6245)
- Fang Yang (ORCID: https://orcid.org/0000-0001-6966-9464)
- Shiyi Xiong (ORCID: https://orcid.org/0009-0004-8433-7758)
- Lu Huo (ORCID: https://orcid.org/0009-0004-8912-0507)
- Chao Liang (ORCID: https://orcid.org/0000-0002-3885-7697)
- Hongyu Zhang (ORCID: https://orcid.org/0000-0001-5159-2673)
- Yingying Han (ORCID: https://orcid.org/0000-0002-9736-6126)
- Qiufang Gong
- Xuefen Zhao (ORCID: https://orcid.org/0000-0001-5720-9495)
Institutions
- Hunan University (CN)
- Wenzhou Medical University (CN)
Publication Details
- Journal
- Nanoscale Advances
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5na00423c
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Ningbo
- Natural Science Foundation of Zhejiang Province