A Purification‐Free Strategy for the Electrochemical Oxidation of the Primary Hydroxy Group in Glycopyranosides
An operationally simple protocol for the electrochemical oxidation of the primary hydroxy group in glycopyranosides is presented. The strategy uses aqueous ammonia as a base and electrolyte, reticulated vitreous carbon (RVC) electrodes, and TEMPO as a mediator. Under these conditions, the ammonium salts of the corresponding uronic acids are obtained in excellent yield upon evaporation of the volatiles, rendering an exceptionally simple protocol.
Authors
- Martin D. Witte (ORCID: https://orcid.org/0000-0003-4660-2974)
- Adriaan J. Minnaard (ORCID: https://orcid.org/0000-0002-5966-1300)
- Sebastian B. Beil (ORCID: https://orcid.org/0000-0003-0373-3843)
- Marios Kidonakis (ORCID: https://orcid.org/0000-0002-5512-257X)
- Ruben L. H. Andringa (ORCID: https://orcid.org/0000-0003-3226-6463)
- Imke M. A. Bartels (ORCID: https://orcid.org/0009-0005-4105-2477)
Institutions
- University of Groningen (NL)
- Max Planck Institute for Chemical Energy Conversion (DE)
Publication Details
- Journal
- ChemElectroChem
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1002/celc.202500140
- Primary Topic
- Carbohydrate Chemistry and Synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministerie van Economische Zaken
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek