Mitochondrial One-Carbon Metabolism Drives CD34-Lineage Cells to Differentiate Into T Follicular Helper Cells to Form Tertiary Lymphoid Organs in Transplant Arteriosclerosis
This study provides insights into the critical role of mitochondrial one-carbon metabolism and MTHFD2 in governing the differentiation of CD34-lineage cells into Tfh cells, which contributes to tertiary lymphoid organ formation in transplant vasculopathy, offering potential therapeutic targets to enhance transplant outcomes.
Authors
- Qingbo Xu (ORCID: https://orcid.org/0000-0003-2474-8155)
- Yao Meng (ORCID: https://orcid.org/0000-0003-0386-6267)
- Jingjing Cai (ORCID: https://orcid.org/0000-0002-7820-536X)
- Yao Lu (ORCID: https://orcid.org/0000-0001-6743-7870)
- Junru Wu (ORCID: https://orcid.org/0000-0002-8593-0703)
- Qingzhong Xiao (ORCID: https://orcid.org/0000-0001-9101-0498)
- Qin Li (ORCID: https://orcid.org/0000-0002-8375-1234)
- Hong Yuan (ORCID: https://orcid.org/0000-0002-3634-2622)
- Liping Peng (ORCID: https://orcid.org/0000-0002-1646-2491)
- Xuejing Sun (ORCID: https://orcid.org/0000-0001-6978-8260)
- Chunyan Weng
- Tian He (ORCID: https://orcid.org/0009-0008-6140-104X)
Institutions
- Central South University (CN)
- Queen Mary University of London (GB)
- Gannan Medical University (CN)
- William Harvey Research Institute (GB)
- Third Xiangya Hospital (CN)
- First Affiliated Hospital Zhejiang University (CN)
Publication Details
- Journal
- Circulation
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1161/circulationaha.125.073691
- Citations
- 4
- Primary Topic
- Atherosclerosis and Cardiovascular Diseases
- Type
- article
- Field-Weighted Citation Impact
- 3.19