Wild Cordyceps sinensis exhibits far lower arsenic accumulation and hepatorenal toxicity in mice compared to equivalent dose of inorganic arsenic
These findings indicate that, at the maximum clinical dose, wild Cordyceps sinensis does not cause measurable hepatorenal toxicity in long-term and exhibits markedly greater safety compared to a mixture of inorganic arsenic compounds (sodium arsenate and sodium arsenite) at an equivalent total arsenic dose.
Authors
- Cen Li (ORCID: https://orcid.org/0000-0003-3958-3269)
- Liang Gao (ORCID: https://orcid.org/0000-0001-5731-8616)
- Jin-Mei Ma
- Yuancan Xiao (ORCID: https://orcid.org/0000-0001-5929-0282)
- Lixin Wei (ORCID: https://orcid.org/0000-0001-5300-6535)
- Hongxia Yang
- Hongtao Bi (ORCID: https://orcid.org/0000-0002-5569-8552)
Institutions
- Chinese Academy of Sciences (CN)
- Institute of Tibetan Plateau Research (CN)
- University of Chinese Academy of Sciences (CN)
- Northwest Institute of Plateau Biology
- University of Pennsylvania (US)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-06-24
- DOI
- https://doi.org/10.3389/fphar.2025.1625045
- Primary Topic
- Therapeutic Uses of Natural Elements
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chinese Academy of Sciences