Excessive Iron Induces Macrophage Dysfunction in the Liver, Causing Adverse Pregnancy Outcomes in Mice
Maternal excess iron may induce inflammatory conditions with macrophage dysfunction in the liver, resulting in pregnancy complications. The reduction in macrophages also induced higher iron levels and adverse effects during pregnancy, suggesting a vicious cycle between excessive iron and macrophage dysfunction during pregnancy.
Authors
- Akari Isobe
- Hisataka Iwata (ORCID: https://orcid.org/0000-0001-7238-8997)
- Sohei Kuribayashi (ORCID: https://orcid.org/0000-0002-0564-6404)
- Ren Ozawa
- Sayaka Shimazaki
- Koumei Shirasuna (ORCID: https://orcid.org/0000-0001-6759-6134)
Institutions
- Tokyo University of Agriculture (JP)
Publication Details
- Journal
- Metabolites
- Published
- 2025-06-24
- DOI
- https://doi.org/10.3390/metabo15070431
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jichi Medical University
- Japan Society for the Promotion of Science