A novel 2-oxopyrrolidine derivative (LN-53) efficiently induces Nrf-2 signaling pathway activation in human epidermal keratinocytes
LN-53 can effectively induce antioxidant mechanisms by promoting Nrf-2 nuclear translocation and suppressing ROS production in human epidermal keratinocytes. These data may suggest that LN-53 can contribute to maintaining redox balance and homeostasis in the skin.
Authors
- Gökhan Arık
- Shirin Kahremany (ORCID: https://orcid.org/0000-0001-5213-2599)
- Arie Gruzman (ORCID: https://orcid.org/0000-0002-8006-4201)
- Lior Nissim (ORCID: https://orcid.org/0000-0001-6495-4741)
- Dilara Karagüzel (ORCID: https://orcid.org/0000-0001-5986-4311)
- Edward E. Korshin (ORCID: https://orcid.org/0000-0002-6318-9942)
- Basak Ezgi Sarac (ORCID: https://orcid.org/0000-0003-1181-4598)
- Çağatay Karaaslan (ORCID: https://orcid.org/0000-0003-4857-0857)
Institutions
- Bar-Ilan University (IL)
- Hacettepe University (TR)
Publication Details
- Journal
- Pharmacological Reports
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1007/s43440-025-00757-y
- Citations
- 1
- Primary Topic
- Genomics, phytochemicals, and oxidative stress
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Bar-Ilan University
- National and Kapodistrian University of Athens