Blood-brain barrier impairment as an early marker of neurodegeneration in late-onset epilepsy of unknown origin
LOEU patients show BBB dysfunction and early changes in CSF biomarker ratios pointing to AD pathology. Qalb increase seems to be unrelated to the pathological changes in CSF AD biomarkers. Future studies should be performed to better understand the neuropathological basis of LOEU and the risk for patients to develop a neurodegenerative disorder.
Authors
- Francesca Izzi (ORCID: https://orcid.org/0000-0003-2490-8761)
- Silvia Maio
- Mariana Fernandes (ORCID: https://orcid.org/0000-0002-7005-2805)
- Nicola Biagio Mercuri (ORCID: https://orcid.org/0000-0001-6700-7491)
- Claudio Liguori (ORCID: https://orcid.org/0000-0003-2845-1332)
- Fabio Placidi (ORCID: https://orcid.org/0000-0002-5214-5581)
- Pagano Andrea
- Alessandro Castelli
Institutions
- University of Rome Tor Vergata (IT)
Publication Details
- Journal
- Epilepsy Research
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1016/j.eplepsyres.2025.107614
- Citations
- 2
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.94