Maternal Electronic Cigarette Exposure Induces Dysregulation of Autophagy via Oxidative Stress/DNA Methylation in Pulmonary Hypertension Offspring
Maternal EC exposure induces oxidative stress and DNA hypomethylation in offspring, leading to anomalous autophagy and exacerbation of PH development. Targeting ATG5-mediated autophagy may represent a novel therapeutic approach for improving PH outcomes in offspring exposed to maternal EC.
Authors
- Hongbin Qiu (ORCID: https://orcid.org/0000-0002-6709-2830)
- Wen Xie (ORCID: https://orcid.org/0000-0002-7314-8175)
- Zewen Chen (ORCID: https://orcid.org/0000-0003-3359-7635)
- Jian Zhuang (ORCID: https://orcid.org/0000-0003-1384-3333)
- Shu-sheng Wen
- Tianyu Chen (ORCID: https://orcid.org/0009-0009-2219-0099)
- Yifan Li (ORCID: https://orcid.org/0009-0005-9473-2695)
- Yong Zhang (ORCID: https://orcid.org/0000-0003-1436-5951)
- Jimei Chen
Institutions
- Guangdong Academy of Medical Sciences (CN)
Publication Details
- Journal
- Current Medical Science
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1007/s11596-025-00074-8
- Citations
- 1
- Primary Topic
- Fatty Acid Research and Health
- Type
- article
- Field-Weighted Citation Impact
- 1.12
Funders
- National Natural Science Foundation of China
- Guangzhou Municipal Science and Technology Project