Chronic tophaceous gout presenting with severe hypercalcemia - A rare clinical entity

Gout is an inflammatory arthritis caused by the accumulation of monosodium urate crystals within the synovial fluid and surrounding tissues. This condition is closely linked to hyperuricaemia, a serum urate concentration of 6.8 mg/dL or higher. If hyperuricaemia is not properly managed, the disease may progress to chronic tophaceous gout, which involves long-term joint damage and deposition of crystal aggregates (tophi) in joints and soft tissues. In this case report, we describe the case of a 62-year-old male who presented with altered mental status, generalised weakness, poor oral intake and diffuse body pain. Laboratory tests revealed severe hypercalcaemia, which is a rare presentation. The patient was treated with intravenous saline hydration, calcitonin and prednisone, which improved kidney function and normalised calcium levels.

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Publication Details

Journal
Current Medicine Research and Practice
Published
2025-05-01
DOI
https://doi.org/10.4103/cmrp.cmrp_23_25
Citations
1
Primary Topic
Gout, Hyperuricemia, Uric Acid
Type
article
Field-Weighted Citation Impact
1.43
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article

Chronic tophaceous gout presenting with severe hypercalcemia - A rare clinical entity

Jagmeet Singh, Ishan Garg, Vikas Garg, Rohit Raina
1 citations
Current Medicine Research and Practice
Gout, Hyperuricemia, Uric Acid
1.43
article

Chronic tophaceous gout presenting with severe hypercalcemia - A rare clinical entity

Jagmeet Singh, Ishan Garg, Vikas Garg, Rohit Raina
article en
1 citations

Abstract

Gout is an inflammatory arthritis caused by the accumulation of monosodium urate crystals within the synovial fluid and surrounding tissues. This condition is closely linked to hyperuricaemia, a serum urate concentration of 6.8 mg/dL or higher. If hyperuricaemia is not properly managed, the disease may progress to chronic tophaceous gout, which involves long-term joint damage and deposition of crystal aggregates (tophi) in joints and soft tissues. In this case report, we describe the case of a 62-year-old male who presented with altered mental status, generalised weakness, poor oral intake and diffuse body pain. Laboratory tests revealed severe hypercalcaemia, which is a rare presentation. The patient was treated with intravenous saline hydration, calcitonin and prednisone, which improved kidney function and normalised calcium levels.

Current Medicine Research and PracticeVol. 15(3)
Central University of Punjab (IN), All India Institute of Medical Sciences Raipur (IN), All India Institute of Medical Sciences Bhopal (IN), Public Works Department Buildings and Roads (IN), All India Institute of Medical Sciences (IN)
Good health and well-being, No poverty
Openalex Percentile: Top 19%
Gout, Hyperuricemia, Uric Acid
1.43
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Chronic tophaceous gout presenting with severe hypercalcemia - A rare clinical entity — Jagmeet Singh, Ishan Garg, et al. · Current Medicine Research and Practice (2025) | TGRS Research Map | TGRS