The duplexity of insulin: The integrated bioinformatics analysis and machine learning identified key genes for type 2 diabetes
Insulin therapy is bidirectional, it can cause islet B cell damage and vascular complications, but also can reduce the level of inflammation and oxidative stress.
Authors
- Xiaomei Bai
- Chunjun Li (ORCID: https://orcid.org/0000-0003-4857-8146)
- Zhenyu Kou
- Shaochong Bu (ORCID: https://orcid.org/0000-0002-9060-7361)
- Nan Gao (ORCID: https://orcid.org/0000-0001-9119-8072)
- Xiteng Chen (ORCID: https://orcid.org/0000-0003-4100-1598)
- Fang Tian (ORCID: https://orcid.org/0000-0003-3153-2336)
- Jun Yang (ORCID: https://orcid.org/0000-0002-0641-8841)
- Yuanfeng Jiang (ORCID: https://orcid.org/0000-0002-6360-7104)
Institutions
- Nankai University (CN)
- Tianjin Nankai Hospital (CN)
- Tianjin Medical University Eye Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Biochemistry and Biophysics Reports
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1016/j.bbrep.2025.102099
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00