Tirzepatide for reduction of morbidity and mortality in adults with obesity: rationale and design of the <scp>SURMOUNT</scp> ‐ <scp>MMO</scp> trial
SURMOUNT-MMO will provide evidence of the clinical benefits of tirzepatide on multiple outcomes among individuals with overweight or obesity but without diabetes. This is the first outcome trial of an incretin medication that assesses both primary and secondary cardiovascular disease prevention.
Authors
- Michelle Strzelecki
- Ania M. Jastreboff (ORCID: https://orcid.org/0000-0003-1446-0991)
- Hannele Yki‐Järvinen (ORCID: https://orcid.org/0000-0001-6766-1549)
- Hiddo J.L. Heerspink (ORCID: https://orcid.org/0000-0002-3126-3730)
- Steven E. Nissen (ORCID: https://orcid.org/0000-0002-7231-6464)
- Denise Mason
- Ali Aminian (ORCID: https://orcid.org/0000-0001-5756-9917)
- Carolyn S.P. Lam (ORCID: https://orcid.org/0000-0003-1903-0018)
- Arun Jayant Sanyal (ORCID: https://orcid.org/0000-0001-8682-5748)
- Can Cui (ORCID: https://orcid.org/0000-0002-9517-7823)
- Amy Bartee
- Karla Hurt
- Bruno Linetzky (ORCID: https://orcid.org/0009-0009-4015-7794)
- Luke J. Laffin (ORCID: https://orcid.org/0000-0002-3262-792X)
- Ele Ferrannini (ORCID: https://orcid.org/0000-0002-1384-1584)
- Paul M. Ridker (ORCID: https://orcid.org/0000-0003-1249-4522)
- Ángel Rodríguez (ORCID: https://orcid.org/0000-0001-8721-9539)
- Kausik K Ray
- Mathijs C. Bunck
- Ambarish Pandey
Institutions
- Brigham and Women's Hospital (US)
- Cleveland Clinic (US)
- University Medical Center Groningen (NL)
- University of Helsinki (FI)
- Harvard University (US)
- National University of Singapore (SG)
- Eli Lilly (United States) (US)
- University of Groningen (NL)
- Virginia Commonwealth University (US)
- Helsinki University Hospital (FI)
- Yale University (US)
- Minerva Foundation (FI)
- Istituto di Fisiologia Clinica (IT)
- The George Institute for Global Health (AU)
- National Heart Centre Singapore (SG)
- Center for Clinical Research (United States) (US)
- Imperial College London (GB)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Obesity
- Published
- 2025-06-22
- DOI
- https://doi.org/10.1002/oby.24332
- Citations
- 18
- Primary Topic
- Pharmacology and Obesity Treatment
- Type
- article
- Field-Weighted Citation Impact
- 25.10
Funders
- Eli Lilly and Company