A Tolerogenic Plasmid Inhibits Autoantibody Production Triggered by Immunization With Human Peptidyl Arginine Deiminase 4
Tolerizing to hPAD4 decreases the production of anti-citrullinated peptide antibodies in mice immunized with hPAD4. This suggests that tolerization to hPAD4 may allow one to switch off ACPAs in RA.
Authors
- Vijetha Kumar
- Isabelle Auger (ORCID: https://orcid.org/0000-0002-1414-8095)
- Matthias von Herrath (ORCID: https://orcid.org/0000-0002-5211-0485)
- Nathalie Lambert (ORCID: https://orcid.org/0000-0001-5817-8686)
- Jean Roudier (ORCID: https://orcid.org/0000-0001-5435-8567)
- Hervé Luche (ORCID: https://orcid.org/0000-0003-4309-8338)
- Johnna D. Wesley (ORCID: https://orcid.org/0000-0002-3693-1101)
- Marielle Mello (ORCID: https://orcid.org/0000-0002-5454-3559)
- Philippe P. Pagni (ORCID: https://orcid.org/0000-0002-9026-4549)
- Eva Frison
- Magali Torres (ORCID: https://orcid.org/0000-0002-7760-3809)
Institutions
- Centre National de la Recherche Scientifique (FR)
- La Jolla Institute for Immunology (US)
- Inserm (FR)
- Novo Nordisk (Denmark) (DK)
- Aix-Marseille Université (FR)
- Novo Nordisk (United States) (US)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1002/art.43295
- Citations
- 2
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- Institut National de la Santé et de la Recherche Médicale