p53 enhances elesclomol-Cu-induced cuproptosis in hepatocellular carcinoma via FDXR-mediated FDX1 upregulation
These findings revealed that p53 enhances elesclomol-Cu-induced cuproptosis in HCC via FDXR-mediated FDX1 upregulation. This study provides mechanistic insights into p53's role in cuproptosis and may serve as a basis for targeting copper metabolism in therapeutic strategies for HCC.
Authors
- Dong Wang (ORCID: https://orcid.org/0000-0002-1623-7104)
- Xianyong Bai
- Honglin Qu (ORCID: https://orcid.org/0000-0001-6420-5492)
- Xuhong Sun
- Xiao Liu (ORCID: https://orcid.org/0009-0004-7336-0194)
- Xiaoyan Li (ORCID: https://orcid.org/0000-0001-6554-6811)
- Jingmin Li (ORCID: https://orcid.org/0009-0005-4153-8215)
- Zhenlin Wang (ORCID: https://orcid.org/0000-0002-3113-4103)
Institutions
- Shandong University of Aeronautics (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-06-24
- DOI
- https://doi.org/10.3389/fonc.2025.1584811
- Citations
- 4
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- National Natural Science Foundation of China