PipC affects the virulence of Salmonella enterica serovar Enteritidis and its deletion strain provides effective immune protection in mice
This study demonstrates that lack of <i>pipC</i> affects <i>SE</i> pathogenicity by decreasing its virulence both <i>in vitro</i> and <i>in vivo</i>. Vaccination of mice with Δ<i>pipC</i> conferred development of an acquired immunity and efficacious protection against experimental systemic infection. These results indicated that the Δ<i>pipC</i> mutant strain can be used in the development of attenuated live vaccines.
Authors
- Zhigang Yan
- Yanying Zhang (ORCID: https://orcid.org/0000-0002-2097-9207)
- Yan‐Dong Li
- Yubin Chen (ORCID: https://orcid.org/0000-0002-9912-7655)
- Qiumei Shi (ORCID: https://orcid.org/0000-0002-4882-6309)
- Chen Li (ORCID: https://orcid.org/0000-0002-8784-8148)
- Yonghui Li
- Yingyu Chen (ORCID: https://orcid.org/0000-0002-1559-5698)
- Xiaowen Yang (ORCID: https://orcid.org/0000-0003-0955-4977)
- Tonglei Wu
- Lu Zhang (ORCID: https://orcid.org/0009-0008-1714-4146)
Institutions
- Huazhong Agricultural University (CN)
- Qinhuangdao Second Hospital (CN)
- Chinese Academy of Agricultural Sciences (CN)
- Ministry of Agriculture and Rural Affairs (CN)
- National Livestock Breeding Center (JP)
- Hebei Normal University of Science and Technology (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-06-24
- DOI
- https://doi.org/10.3389/fmicb.2025.1631008
- Primary Topic
- Salmonella and Campylobacter epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Beijing University of Agriculture
- National Key Research and Development Program of China