6-Methoxydihydroavicine is a benzophenanthridine alkaloid with anti-leukemia activity
Our findings demonstrate that 6-methoxydihydroavicine exerts strong cytotoxic effects against AML cells through mitochondrial dysfunction and ROS-mediated apoptosis. As a natural, plant-derived compound with distinct anti-AML properties, 6-methoxydihydroavicine represents a promising candidate for further development as a therapeutic agent for AML.
Authors
- Paul A. Spagnuolo (ORCID: https://orcid.org/0000-0002-2431-4368)
- Yingying Yang (ORCID: https://orcid.org/0000-0003-2919-9853)
Institutions
- University of Guelph (CA)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-06-24
- DOI
- https://doi.org/10.3389/fphar.2025.1621050
- Citations
- 1
- Primary Topic
- Cancer therapeutics and mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.81