Taurine-mediated metabolic immune crosstalk indicates and promotes immunosuppression with anti-PD-1 resistance in bladder cancer
This study establishes that taurine metabolic dysregulation reconfigures intercellular signaling within the BLCA TME, driving immunosuppression and tumor progression. The TMs framework enables robust patient stratification and provides a mechanistic rationale for therapeutic strategies targeting TM in conjunction with immune checkpoint inhibitors, thus paving the way for advanced precision medicine approaches in BLCA.
Authors
- Hongyun Zhao (ORCID: https://orcid.org/0000-0002-1251-3888)
- Fengwei Nong (ORCID: https://orcid.org/0000-0003-0484-2443)
- Zhengfang Liang (ORCID: https://orcid.org/0000-0003-3750-7238)
- Runmin Chen
- Zhenjie Li (ORCID: https://orcid.org/0000-0002-3054-3589)
- Yongping Huang (ORCID: https://orcid.org/0000-0002-3266-1327)
Institutions
- Affiliated Hospital of Youjiang Medical University for Nationalities (CN)
- First Affiliated Hospital of Jinan University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-24
- DOI
- https://doi.org/10.3389/fimmu.2025.1618439
- Citations
- 1
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.81